The level of IL-6, which has been shown to be abundantly secreted by activated dendritic cells (DCs), was remarkably elevated. To determine the mechanisms, we investigated the production of cytokines in the liver. In vitro experiments also showed that Treg cells from mice with BA had a diminished suppressive effect on Th17 cell generation. The proportion of Th17 cells at 7 days post-infection was decreased if Treg cells isolated from normal adult mice, but not Treg cells from the livers of mice with BA, were intraperitoneally transferred on day 5 of life. However, the absolute numbers of Treg and Th17 cells were both increased in liver of RRV-injected mice compared to saline-injected mice. Furthermore, we found that in mice with BA, the percentage of CD4 +CD25 highFoxp3 + T regulatory (Treg) cells decreased along with the increased percentage of Th17 cells. By depleting the Th17 cells, the BA symptoms (onset of jaundice, acholic stools and retarded growth) were attenuated and the survival rate was improved. Here, we identified an increased T helper 17 (Th17) cell population in a BA mode. Several cell types are considered to be effector cells in bile duct injury in rhesus rotavirus (RRV)-induced experimental biliary atresia (BA).
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |